There are billions of these foods in our body, and their total weight is about 100 grams, which is about the weight of a piece of soap. If there are too many antibodies in our body, then they must be safe and very important, right?
Antibodies may be the safest treatment and have many important functions. One of them is to protect and cure infections caused by viruses.
The human immune system can produce specific antibodies against each virus. These antibodies firmly bind to the virus and prevent it from infecting our cells, so-called neutralizing antibodies.
To stop the spread of COVID-19, billions of people will need to have antibodies to defend against new coronaviruses. Therefore, the question is how do we isolate and produce a sufficient amount of neutralizing antibodies to serve everyone who needs them, including research laboratories and pharmaceutical companies?
What are the antibodies?
Our immune system produces antibodies against foreign pathogens (whether bacteria, viruses, or fungi).
Antibodies are Y-shaped blood proteins produced by white blood cells called “B cells.” They neutralize pathogens by attaching to the surface of pathogens, preventing them from entering our cells, and sending a signal to our immune system to clear pathogens, thereby neutralizing pathogens.
At any given time, various antibodies will float inside the human body in search of attackable foreign pathogens. When a particular virus infects our bodies, our immune system will try to produce enough specific antibodies against it before the infection becomes overwhelmed.
If we already have antibodies against pathogens, this process can proceed more quickly and can prevent infections more successfully.
Looking for antibodies to treat COVID-19
Chinese researchers have studied in an animal model of SARS-CoV-2 infection. In this model, mice are engineered with human ACE2 receptors to enable viruses to infect cells. These monoclonal antibodies can effectively block viruses. Another paper published on the Cell using the same model reported similar findings.
Other published reports describe the neutralization of SARS-CoV-2 mAb but have not been evaluated in animal models.
Why are animal models so important? Because many other factors may affect the effectiveness of antibodies in organisms that cannot be simulated in Petri dishes. For example, how long have monoclonal antibodies been in the body? Are they safe?
Animal models can provide preliminary safety data. In addition to animal models, the key monoclonal antibody characteristic to consider is whether monoclonal antibodies can be efficiently produced in a stable and safe form for human use.